A study on cognitive functions in chronic kidney disease patients in a government medical college, Kerala
Muhammad, CV Shaji, KA Kabeer, S Gomathy
Introduction: Cognitive impairment (CI) is more common in patients with CKD than in the general population. But it remains poorly recognized clinically and, therefore, underconsidered in the care of renal disease patients. Methodology: This was an Observational study on 50 CKD patients, over 1-year period., conducted at Nephrology and Medicine wards. Cognitive assessments were done using MoCA scale. MoCA score of various stages of CKD were compared. Results: The mean age of the study group was 47.14 ± 10.8. Male to female ratio was 3:2. Etiologies of CKD were diabetes (38%), systemic hypertension (18%), chronic glomerulonephritis (14 %). Mean years of schooling was 8.74 ± 2.74 years. 46% of patients had stage 5 CKD and 18% had stage 4. 50% of patients were on hemodialysis (HD). Mean MoCA score observed was 25.40 ± 2.76. MoCA score of < 26 was observed in 26 out 50 patients. No significant difference between mean MoCA scores of males and females. Pearson correlation between MoCA score, eGFR and HD, showed more cognitive impairment in those on HD and with advanced CKD. Among the various cognitive tests assessed most common abnormality was for word fluency (78%) followed by Trail making test (56%) and abstraction (54%). Conclusion: CI is more in patients with advanced CKD patients and in those on HD. Most of the abnormality observed were in non - amnestic domains of cognition. Most of the abnormality observed were in non - amnestic domains of cognition.