Out-migration of people is the most common phenomenon across all countries of the world which has received considerable attention from the policymakers. Like many other developing countries of the world, in India and especially in the Northeastern part of the country the extent of out-migration has increased in the recent past. Out-migration is a recent problem in Assam. Historically, Assam is a migrant-receiving state due to availability of livelihood sources. But with respect to the development of Assam, the rate of employment generation is very low. So people out-migrate to other state and countries from their usual place of residence in search of employment. Out-migration has been recognized to contribute significantly in bringing down the economic disparities across regions. Using NSSO 64th Round (2007-2008) unit-level data comprising information of 1427 out-migrants in Assam, the paper attempts to study the determinants of out-migration in Assam by using binary logistic regression analysis. Findings of the study show that out-migration from Assam has been significantly affected by both individual and household characteristics. Individual characteristics like age, marital status, gender and education attainment have an immense influence on the decision to migrate. Similarly, household characteristics like the size of the household, household type, caste, social group, land possession and religion also have a significant impact on the decision to out-migrate.