Review on chemical synthesis and antimalarial activities of Amopyroqunine
Yihunie Bekalu, Osman Ahmed
Malaria is one of the major death causing problems for human in tropical and sub tropical area of the world largely in Africa. For these, scholars investigate antimalarial drug based on evaluating the risk of exposure to infection preventing mosquito bites giving as medical cure. Antimalarial drug act by distributing the polymerization and the detoxification by any of heme, thus killing the parasites with is own metabolic wastes. The main class of active schizonetocide is 4- aminoqunoline and 8-aminoqunoline. Quinine is isolated from cinchona bark replaced the cured preparation and continued to be the major antimalarial drug till 1942. The one which is grouped under 4-aminoquinine is Amopyroquanine. Amopyroquanine is an anti-malarial compound chemically and functionally related to chloroquine (CQ). Currently, it is used (in combination with other antimalarial) as the first choice to treat complicated plasmodium faliciparim. malaria in some countries in Africa and south America this Amopyroquanine is one of anti-malarial drug synthesized industrially and less toxic compared to the other types of anti-malarial drugs for treatment of malaria.