Menstruation is a monthly cycle where in a formed layer of the womb sheds. During this biological process, a female can experience many changes, which might be physical and psychological. The physiological effects may be subtle, but at elite level sufficient to influence performance. The psychological correlates may be affected more obviously and more detrimentally. Psychological well-being is usually conceptualized as a combination of positive affective states such as functioning with optimal effectiveness in social life. It is the combination of feeling good and functioning effectively that marks on performance, personality, behavior, coping capabilities and more importantly the ability to achieve one’s full potential of an individual. Each individual has their own way of dealing and facing the day-to-day happenings, all it requires is a greater energy and balanced mind. Nevertheless, these factors may not be exercised in the same manner in different time and part of lifespan. One such situation is menstrual cycle among females. India which is tagged as a cultural and traditional city, women hesitate even to talk about menstruation or issues pertaining to menstrual cycle. This attitude results in internal sufferings. Keeping this dilemma in mind, with the aim to understand the problems, causes, consequences of the menstruation in social and academic performance with special reference to college students who has to focus on both the dimensions. The study adopts exploratory research design considering 60 postgraduate students as respondents who are in their early 20’s. Focused areas are self-management, social performance and academic performance of students during menstruation. Data was elicited through interview schedule and analyzed using simple descriptive, contingency coefficient and chi-square test. The study reveals that menstruation makes them vulnerable to stress, anxiety, behavioral change, low concentration and average academic performance during the menstrual cycle specially during the first two days.